Comments for All Things Stem Cell

Comment on Induced Pluripotent Stem Cells: A New Stem Cell Line with a Long History by admin

admin — Sat, 26 Feb 2011 05:40:43 +0000

Hi Mark,

Thank you for your interest in AllThingsStemCell! That’s a good question. In short, there is no blastocyst-like stage — when the somatic cells are reprogrammed, they’re immediately cultured as cells in normal adherent culture. Basically, the cells to be reprogrammed are removed from their normal culture system and exposed to the genes (in a gene delivery system), then put back into a new culture system. Since human embryonic stem cells grow in an adherent culture system, for cells being reprogrammed this “new culture system” is an adherent culture system (to try and mimic the conditions the embryonic stem cells want to be happy). (See “Figure 2″ here for a picture of what the hESCs look like in normal adherent culture: http://www.allthingsstemcell.com/2009/04/human_embryonic_stem_cells/ )

Thanks for reading and commenting!

Comment on Induced Pluripotent Stem Cells: A New Stem Cell Line with a Long History by Mark

Mark — Fri, 25 Feb 2011 21:37:48 +0000

When the somatic cells are initially reprogrammed with the 4 genes and then allowed to divide, do they go to a blastocyst-like stage in which cells are taken to generate and perpetuate the iPS, or is it something different from that?

Comment on Visual Stem Cell Glossary by All Things Stem Cell » Progenitor Hair Populations are Key to Understanding Male Pattern Baldness

Wed, 09 Feb 2011 07:37:20 +0000

[...] known that stem cells, the key players in regenerative processes in the body, play a key role in continually making new [...]

Comment on Induced Pluripotent Stem Cells: A New Stem Cell Line with a Long History by All Things Stem Cell » Creating Patient-Specific Stem Cells through Somatic Cell Nuclear Transfer

Tue, 09 Nov 2010 07:05:40 +0000

[...] pluripotent stem cells: The history and biology of human iPSCs were explored previously in “Induced Pluripotent Stem Cells: A New Stem Cell Line with a Long History.” In essence, iPSCs, which were first created with mouse cells in 2006 (Takahashi and Yamanaka, [...]

Comment on Visual Stem Cell Glossary by All Things Stem Cell » Creating Patient-Specific Stem Cells through Somatic Cell Nuclear Transfer

Tue, 09 Nov 2010 07:05:21 +0000

[...] of the major hurdles that needs to be overcome in the field of regenerative medicine is the issue of immune rejection, or preventing a patient’s body from rejecting a tissue [...]

Comment on Stem Cells Discovered in Menstrual Blood: Endometrial Regenerative Stem Cells by Thomas Ichim

Thomas Ichim — Wed, 13 Oct 2010 05:56:07 +0000

In case you dont know, im biased since im CEO of Medistem

Comment on Stem Cells Discovered in Menstrual Blood: Endometrial Regenerative Stem Cells by Thomas Ichim

Thomas Ichim — Wed, 13 Oct 2010 05:55:41 +0000

There are more and more exciting papers coming out in this area. I recently saw one by a Chinese group making islets and one by the Cryo-Cell collaborator Paul Sanberg treating stroke. In my opinion ERC are “the way”….but of course im biased

Tom

Comment on Cancer Vaccines: Using Embryonic Tissues and Stem Cells to Vaccinate Against Cancer by W.

W. — Tue, 11 May 2010 05:50:46 +0000

Cool. This was interesting.

Comment on Induced Pluripotent Stem Cells: A New Stem Cell Line with a Long History by All Things Stem Cell » Cancer Vaccines: Using Embryonic Tissues and Stem Cells to Vaccinate Against Cancer

Tue, 04 May 2010 07:03:42 +0000

[...] stem cells (hESCs) (which are stem cells isolated from the inner cell mass of a blastocyst) and induced pluripotent stem cells (iPSCs) (which are adult cells that have been reprogrammed to be hESC-like). These similarities [...]

Comment on Human Embryonic Stem Cells: A Decade of Discovery, Controversy, and Potential by All Things Stem Cell » Cancer Vaccines: Using Embryonic Tissues and Stem Cells to Vaccinate Against Cancer

Tue, 04 May 2010 07:03:14 +0000

[...] recently published paper showed that mice with colon cancer can be “vaccinated” with human embryonic stem cells and have a significant immune response against the cancer (Li et al., 2009). This study relates to [...]